5EBV
Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with inhibitor 11c and CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005829 | cellular_component | cytosol |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030649 | biological_process | aminoglycoside antibiotic catabolic process |
| A | 0033661 | biological_process | effector-mediated defense to host-produced reactive oxygen species |
| A | 0034054 | biological_process | symbiont-mediated suppression of host defense-related programmed cell death |
| A | 0034069 | molecular_function | aminoglycoside N-acetyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043655 | cellular_component | host extracellular space |
| A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0051701 | biological_process | biological process involved in interaction with host |
| A | 0052032 | biological_process | symbiont-mediated perturbation of host inflammatory response |
| A | 0052040 | biological_process | symbiont-mediated perturbation of host programmed cell death |
| A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| A | 0061733 | molecular_function | peptide-lysine-N-acetyltransferase activity |
| A | 0097691 | cellular_component | bacterial extracellular vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue COA A 501 |
| Chain | Residue |
| A | VAL87 |
| A | TYR126 |
| A | ASP260 |
| A | HOH646 |
| A | ARG92 |
| A | ARG93 |
| A | ARG94 |
| A | GLY95 |
| A | LEU96 |
| A | LEU97 |
| A | ARG98 |
| A | ILE125 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 5LR A 502 |
| Chain | Residue |
| A | PHE24 |
| A | ASP26 |
| A | PHE27 |
| A | ALA33 |
| A | TRP36 |
| A | ARG37 |
| A | SER83 |
| A | PHE84 |
| A | VAL85 |
| A | HIS119 |
| A | GLU401 |
| A | PHE402 |
| A | HOH623 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | THR269 |
| A | THR398 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:21628583 |
| Chain | Residue | Details |
| A | ALA120 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor; via carboxylate => ECO:0000305|PubMed:21628583 |
| Chain | Residue | Details |
| A | VAL396 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0007744|PDB:3RYO |
| Chain | Residue | Details |
| A | THR79 | |
| A | VAL115 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22547814, ECO:0000305|PubMed:21628583, ECO:0000305|PubMed:24106131, ECO:0000305|PubMed:27010218, ECO:0007744|PDB:3RYO |
| Chain | Residue | Details |
| A | VAL87 |
