5DY5
Crystal structure of human Sirt2 in complex with a SirReal probe fragment
Summary for 5DY5
Entry DOI | 10.2210/pdb5dy5/pdb |
Descriptor | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, N-(5-{3-[(1-benzyl-1H-1,2,3-triazol-4-yl)methoxy]benzyl}-1,3-thiazol-2-yl)-2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamide, ... (7 entities in total) |
Functional Keywords | hydrolase, hydrolase inhibitor complex |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6 |
Total number of polymer chains | 1 |
Total formula weight | 35430.32 |
Authors | Rumpf, T.,Gerhardt, S.,Einsle, O.,Jung, M. (deposition date: 2015-09-24, release date: 2016-01-20, Last modification date: 2024-01-10) |
Primary citation | Schiedel, M.,Rumpf, T.,Karaman, B.,Lehotzky, A.,Gerhardt, S.,Ovadi, J.,Sippl, W.,Einsle, O.,Jung, M. Structure-Based Development of an Affinity Probe for Sirtuin 2. Angew.Chem.Int.Ed.Engl., 55:2252-2256, 2016 Cited by PubMed: 26748890DOI: 10.1002/anie.201509843 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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