5DWU
Beta common receptor in complex with a Fab
Summary for 5DWU
Entry DOI | 10.2210/pdb5dwu/pdb |
Descriptor | Cytokine receptor common subunit beta, Fab - Heavy Chain, Fab - Light Chain, ... (5 entities in total) |
Functional Keywords | fab complex, antigen recognition, therapeutic antibody, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 96608.93 |
Authors | Dhagat, U.,Parker, M.W. (deposition date: 2015-09-23, release date: 2015-12-30, Last modification date: 2020-07-29) |
Primary citation | Panousis, C.,Dhagat, U.,Edwards, K.M.,Rayzman, V.,Hardy, M.P.,Braley, H.,Gauvreau, G.M.,Hercus, T.R.,Smith, S.,Sehmi, R.,McMillan, L.,Dottore, M.,McClure, B.J.,Fabri, L.J.,Vairo, G.,Lopez, A.F.,Parker, M.W.,Nash, A.D.,Wilson, N.J.,Wilson, M.J.,Owczarek, C.M. CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors. Mabs, 8:436-453, 2016 Cited by PubMed: 26651396DOI: 10.1080/19420862.2015.1119352 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.97 Å) |
Structure validation
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