5DF1

Iridoid synthase from Catharanthus roseus - ternary complex with NADP+ and geranic acid

Summary for 5DF1

Entry DOI	10.2210/pdb5df1/pdb
Descriptor	Iridoid synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2E)-3,7-dimethylocta-2,6-dienoic acid, ... (6 entities in total)
Functional Keywords	oxidoreductase, iridoid synthase, short chain dehydrogenase, nadph-dependent, catharanthus roseus
Biological source	Catharanthus roseus (Madagascar periwinkle)
Cellular location	Cytoplasm, cytosol : K7WDL7
Total number of polymer chains	2
Total formula weight	85051.78
Authors	Caputi, L.,Kries, H.,Stevenson, C.E.M.,Kamileen, M.O.,Sherden, N.H.,Geu-Flores, F.,Lawson, D.M.,O'Connor, S.E. (deposition date: 2015-08-26, release date: 2015-10-28, Last modification date: 2024-01-10)
Primary citation	Kries, H.,Caputi, L.,Stevenson, C.E.,Kamileen, M.O.,Sherden, N.H.,Geu-Flores, F.,Lawson, D.M.,O'Connor, S.E. Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat.Chem.Biol., 12:6-8, 2016 Cited by PubMed: 26551396 DOI: 10.1038/nchembio.1955 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation