5D7Y
Crystal structure of Hepatitis B virus T=4 capsid in complex with the allosteric modulator HAP18
Summary for 5D7Y
Entry DOI | 10.2210/pdb5d7y/pdb |
Descriptor | Capsid protein, methyl (4R)-4-(2-chloro-4-fluorophenyl)-6-{[4-(3-hydroxypenta-1,4-diyn-3-yl)piperidin-1-yl]methyl}-2-(pyridin-2-yl)-1,4-dihydropyrimidine-5-carboxylate (2 entities in total) |
Functional Keywords | capsid, core protein, hepadnavirus, icosahedral, assembly effector, assembly accelerator, allosteric modulator, hap, virus-inhibitor complex, virus/inhibitor |
Biological source | Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D) |
Total number of polymer chains | 4 |
Total formula weight | 68334.64 |
Authors | Venkatakrishnan, B.,Katen, S.P.,Zlotnick, A. (deposition date: 2015-08-14, release date: 2016-02-17, Last modification date: 2023-09-27) |
Primary citation | Venkatakrishnan, B.,Katen, S.P.,Francis, S.,Chirapu, S.,Finn, M.G.,Zlotnick, A. Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket. J.Virol., 90:3994-4004, 2016 Cited by PubMed: 26842475DOI: 10.1128/JVI.03058-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.894 Å) |
Structure validation
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