5D10
Kinase domain of cSrc in complex with RL236
Summary for 5D10
Entry DOI | 10.2210/pdb5d10/pdb |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-[4-({4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}oxy)phenyl]prop-2-enamide (3 entities in total) |
Functional Keywords | kinase inhibitor, drug resistance, transferase |
Biological source | Gallus gallus (Chicken) |
Cellular location | Cell membrane : P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66414.59 |
Authors | Becker, C.,Mayer-Wrangowski, S.C.,Julian, E.,Rauh, D. (deposition date: 2015-08-03, release date: 2015-09-02, Last modification date: 2024-01-10) |
Primary citation | Engel, J.,Richters, A.,Getlik, M.,Tomassi, S.,Keul, M.,Termathe, M.,Lategahn, J.,Becker, C.,Mayer-Wrangowski, S.,Grutter, C.,Uhlenbrock, N.,Krull, J.,Schaumann, N.,Eppmann, S.,Kibies, P.,Hoffgaard, F.,Heil, J.,Menninger, S.,Ortiz-Cuaran, S.,Heuckmann, J.M.,Tinnefeld, V.,Zahedi, R.P.,Sos, M.L.,Schultz-Fademrecht, C.,Thomas, R.K.,Kast, S.M.,Rauh, D. Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach. J.Med.Chem., 58:6844-6863, 2015 Cited by PubMed: 26275028DOI: 10.1021/acs.jmedchem.5b01082 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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