4ZZI

SIRT1/Activator/Inhibitor Complex

Summary for 4ZZI

• Entry DOI: 10.2210/pdb4zzi/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-1, (3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide, 4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide, ... (5 entities in total)
• Functional Keywords: sirtuin, activator, deacylase, complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus, PML body. SirtT1 75 kDa fragment: Cytoplasm: Q96EB6
• Total number of polymer chains: 1
• Total formula weight: 41067.64

Authors

Dai, H. (deposition date: 2015-05-22, release date: 2015-07-15, Last modification date: 2023-09-27)

• Primary citation: Dai, H.,Case, A.W.,Riera, T.V.,Considine, T.,Lee, J.E.,Hamuro, Y.,Zhao, H.,Jiang, Y.,Sweitzer, S.M.,Pietrak, B.,Schwartz, B.,Blum, C.A.,Disch, J.S.,Caldwell, R.,Szczepankiewicz, B.,Oalmann, C.,Yee Ng, P.,White, B.H.,Casaubon, R.,Narayan, R.,Koppetsch, K.,Bourbonais, F.,Wu, B.,Wang, J.,Qian, D.,Jiang, F.,Mao, C.,Wang, M.,Hu, E.,Wu, J.C.,Perni, R.B.,Vlasuk, G.P.,Ellis, J.L.; Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.; Nat Commun, 6:7645-7645, 2015; PubMed: 26134520; DOI: 10.1038/ncomms8645

Experimental method

X-RAY DIFFRACTION (2.7346 Å)