4ZZI
SIRT1/Activator/Inhibitor Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-1 | polymer | 356 | 40125.3 | 1 | UniProt (Q96EB6) Pfam (PF02146) | Homo sapiens (Human) | hSIRT1,Regulatory protein SIR2 homolog 1,SIR2-like protein 1,hSIR2 |
| 2 | B (A) | (3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide | non-polymer | 493.5 | 1 | Chemie (4TQ) | |||
| 3 | C (A) | 4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide | non-polymer | 383.5 | 1 | Chemie (1NS) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 183 - 632 (UniProt: Q96EB6)
| PDB | External Database | Details |
|---|---|---|
| Gly 633 | - | expression tag |
| Gly 634 | - | expression tag |
| Gly 635 | - | expression tag |
| Ser 636 | - | expression tag |
| Gly 637 | - | expression tag |
| Gly 638 | - | expression tag |
| Gly 639 | - | expression tag |
| Ser 640 | - | expression tag |
| Gln 641 | - | expression tag |
| Tyr 642 | - | expression tag |
| Leu 643 | - | expression tag |
| Phe 644 | - | expression tag |
| Leu 645 | - | expression tag |
| Pro 646 | - | expression tag |
| Pro 647 | - | expression tag |
| Asn 648 | - | expression tag |
| Arg 649 | - | expression tag |
| Tyr 650 | - | expression tag |
| Ile 651 | - | expression tag |
| Phe 652 | - | expression tag |
| His 653 | - | expression tag |
| Gly 654 | - | expression tag |
| Ala 655 | - | expression tag |
| Glu 656 | - | expression tag |
| Val 657 | - | expression tag |
| Tyr 658 | - | expression tag |
| Ser 659 | - | expression tag |
| Asp 660 | - | expression tag |
| Ser 661 | - | expression tag |
| Glu 662 | - | expression tag |
| Asp 663 | - | expression tag |
| Asp 664 | - | expression tag |
| Val 665 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40125.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 942.4 | |
| All* | Total formula weight | 41067.6 |
