4ZZI
SIRT1/Activator/Inhibitor Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue 4TQ A 701 |
| Chain | Residue |
| A | LEU206 |
| A | THR209 |
| A | PRO211 |
| A | PRO212 |
| A | ILE223 |
| A | ASN226 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 1NS A 702 |
| Chain | Residue |
| A | PHE273 |
| A | PHE297 |
| A | GLN345 |
| A | ASN346 |
| A | ILE347 |
| A | ASP348 |
| A | HIS363 |
| A | VAL412 |
| A | PHE414 |
| A | HOH808 |
| A | ALA262 |
| A | ILE270 |
| A | ASP272 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 703 |
| Chain | Residue |
| A | CYS371 |
| A | CYS374 |
| A | CYS395 |
| A | CYS398 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:11672523, ECO:0000269|PubMed:12006491, ECO:0000269|PubMed:12535671, ECO:0000269|PubMed:17290224, ECO:0000269|PubMed:18004385, ECO:0000269|PubMed:18235501, ECO:0000269|PubMed:18485871, ECO:0000269|PubMed:19934257, ECO:0000269|PubMed:25406032, ECO:0000269|PubMed:28497810, ECO:0000269|PubMed:38512451 |
| Chain | Residue | Details |
| A | HIS363 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q8IXJ6 |
| Chain | Residue | Details |
| A | GLY261 | |
| A | GLN345 | |
| A | GLY440 | |
| A | ASN465 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00236 |
| Chain | Residue | Details |
| A | CYS371 | |
| A | CYS374 | |
| A | CYS395 | |
| A | CYS398 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS482 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q923E4 |
| Chain | Residue | Details |
| A | LYS238 | |
| A | LYS377 | |
| A | LYS430 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q923E4 |
| Chain | Residue | Details |
| A | CYS395 | |
| A | CYS398 |
