4ZZI
SIRT1/Activator/Inhibitor Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue 4TQ A 701 |
| Chain | Residue |
| A | LEU206 |
| A | THR209 |
| A | PRO211 |
| A | PRO212 |
| A | ILE223 |
| A | ASN226 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 1NS A 702 |
| Chain | Residue |
| A | PHE273 |
| A | PHE297 |
| A | GLN345 |
| A | ASN346 |
| A | ILE347 |
| A | ASP348 |
| A | HIS363 |
| A | VAL412 |
| A | PHE414 |
| A | HOH808 |
| A | ALA262 |
| A | ILE270 |
| A | ASP272 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 703 |
| Chain | Residue |
| A | CYS371 |
| A | CYS374 |
| A | CYS395 |
| A | CYS398 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Region: {"description":"Required for interaction with the sumoylated form of CCAR2","evidences":[{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11672523","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12006491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17290224","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18235501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18485871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19934257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28497810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38512451","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8IXJ6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
