4ZX6
X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s
Summary for 4ZX6
Entry DOI | 10.2210/pdb4zx6/pdb |
Related | 3EBG 4ZW3 4ZW5 4ZW6 4ZW7 4ZW8 4ZX3 4ZX4 4ZX5 |
Descriptor | M1 family aminopeptidase, ZINC ION, N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide, ... (7 entities in total) |
Functional Keywords | m1 alanyl-aminopeptidase, protease, inhibitor, hydroxamic acid, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Plasmodium falciparum (isolate FcB1 / Columbia) |
Total number of polymer chains | 1 |
Total formula weight | 104639.49 |
Authors | Drinkwater, N.,McGowan, S. (deposition date: 2015-05-20, release date: 2016-03-30, Last modification date: 2023-09-27) |
Primary citation | Drinkwater, N.,Vinh, N.B.,Mistry, S.N.,Bamert, R.S.,Ruggeri, C.,Holleran, J.P.,Loganathan, S.,Paiardini, A.,Charman, S.A.,Powell, A.K.,Avery, V.M.,McGowan, S.,Scammells, P.J. Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions. Eur.J.Med.Chem., 110:43-64, 2016 Cited by PubMed: 26807544DOI: 10.1016/j.ejmech.2016.01.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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