4ZX6

X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1101

Chain	Residue
A	HIS496
A	HIS500
A	GLU519
A	4U61102

---

site_id	AC2
Number of Residues	25
Details	binding site for residue 4U6 A 1102

Chain	Residue
A	VAL459
A	GLY460
A	ALA461
A	GLU463
A	ARG489
A	HIS496
A	GLU497
A	HIS500
A	GLU519
A	GLU572
A	ASN573
A	TYR575
A	TYR580
A	MET1034
A	ZN1101
A	DMS1105
A	DMS1106
A	HOH1221
A	HOH1392
A	HOH1434
A	THR305
A	GLN317
A	GLU319
A	ALA320
A	ASN458

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 1103

Chain	Residue
A	ASP438
A	HOH1378
A	HOH1572
A	HOH1712
A	HOH2061
A	HOH2146

---

site_id	AC4
Number of Residues	2
Details	binding site for residue DMS A 1104

Chain	Residue
A	VAL245
A	PHE275

---

site_id	AC5
Number of Residues	7
Details	binding site for residue DMS A 1105

Chain	Residue
A	TYR575
A	THR576
A	THR577
A	TYR580
A	4U61102
A	DMS1106
A	HOH1622

---

site_id	AC6
Number of Residues	4
Details	binding site for residue DMS A 1106

Chain	Residue
A	TYR575
A	THR1037
A	4U61102
A	DMS1105

---

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 1107

Chain	Residue
A	HIS394
A	TYR411
A	ARG448
A	HOH1432

---

site_id	AC8
Number of Residues	5
Details	binding site for residue DMS A 1108

Chain	Residue
A	GLN673
A	TYR674
A	THR675
A	LYS684
A	HOH1419

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHEYFHQY

Chain	Residue	Details
A	VAL493-TYR502

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P15144

Chain	Residue	Details
A	GLU497

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3EBI, ECO:0007744|PDB:3Q43

Chain	Residue	Details
A	GLU319
A	GLY460
A	GLU463

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3Q43

Chain	Residue	Details
A	ALA461

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:19196988, ECO:0000269|PubMed:21366301, ECO:0000269|PubMed:21844374, ECO:0000269|PubMed:23713488, ECO:0000269|PubMed:23897806, ECO:0000269|PubMed:25299353, ECO:0000269|PubMed:25645579, ECO:0000269|PubMed:26406322, ECO:0000269|PubMed:26807544, ECO:0000269|PubMed:30537832, ECO:0000269|PubMed:32182520, ECO:0000269|Ref.21, ECO:0000269|DOI:10.1016/j.cclet.2021.09.102, ECO:0000312|PDB:3T8V, ECO:0000312|PDB:5Y1Q, ECO:0007744|PDB:3EBG, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3EBI, ECO:0007744|PDB:3Q43, ECO:0007744|PDB:3Q44, ECO:0007744|PDB:4J3B, ECO:0007744|PDB:4K5L, ECO:0007744|PDB:4K5M, ECO:0007744|PDB:4K5N, ECO:0007744|PDB:4K5O, ECO:0007744|PDB:4K5P, ECO:0007744|PDB:4R5T, ECO:0007744|PDB:4R5V, ECO:0007744|PDB:4R5X, ECO:0007744|PDB:4X2U, ECO:0007744|PDB:4ZQT, ECO:0007744|PDB:4ZW3, ECO:0007744|PDB:4ZW5, ECO:0007744|PDB:4ZW6, ECO:0007744|PDB:4ZW7, ECO:0007744|PDB:4ZW8, ECO:0007744|PDB:4ZX3, ECO:0007744|PDB:4ZX4, ECO:0007744|PDB:4ZX5, ECO:0007744|PDB:4ZX6, ECO:0007744|PDB:5XM7, ECO:0007744|PDB:5Y19, ECO:0007744|PDB:5Y1H, ECO:0007744|PDB:5Y1K, ECO:0007744|PDB:5Y1R, ECO:0007744|PDB:5Y1S, ECO:0007744|PDB:5Y1T, ECO:0007744|PDB:5Y1V, ECO:0007744|PDB:5Y1W, ECO:0007744|PDB:5Y1X, ECO:0007744|PDB:5Y3I, ECO:0007744|PDB:6EA1, ECO:0007744|PDB:6EA2, ECO:0007744|PDB:6EAA, ECO:0007744|PDB:6EAB, ECO:0007744|PDB:6EE3, ECO:0007744|PDB:6EE4, ECO:0007744|PDB:6EE6, ECO:0007744|PDB:6EED, ECO:0007744|PDB:6SBQ, ECO:0007744|PDB:6SBR

Chain	Residue	Details
A	HIS496
A	HIS500
A	GLU519

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Important for substrate specificity => ECO:0000269|PubMed:23897806

Chain	Residue	Details
A	VAL459

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144

Chain	Residue	Details
A	TYR580

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Cleavage => ECO:0000305|PubMed:21659511

Chain	Residue	Details
A	GLN795

---