4ZX6
X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10s
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | M1 family aminopeptidase | polymer | 890 | 103760.7 | 1 | UniProt (O96935) Pfam (PF17900) Pfam (PF01433) Pfam (PF11940) Pfam (PF17432) In PDB | Plasmodium falciparum (isolate FcB1 / Columbia) | Pfa-M1 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | N-{(1R)-2-(hydroxyamino)-1-[3'-(N'-hydroxycarbamimidoyl)biphenyl-4-yl]-2-oxoethyl}-2,2-dimethylpropanamide | non-polymer | 384.4 | 1 | Chemie (4U6) | |||
4 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
5 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
6 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
7 | water | water | 18.0 | 954 | Chemie (HOH) |
Sequence modifications
A: 195 - 1084 (UniProt: O96935)
PDB | External Database | Details |
---|---|---|
Gln 213 | Asn 213 | engineered mutation |
Gln 223 | Asn 223 | engineered mutation |
Pro 378 | His 378 | engineered mutation |
Gln 501 | Asn 501 | engineered mutation |
Gln 745 | Asn 745 | engineered mutation |
Gln 795 | Asn 795 | engineered mutation |
Gln 1069 | Asn 1069 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 103760.7 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 878.8 | |
All* | Total formula weight | 104639.5 |