4ZX2

Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid

4ZX2 の概要

• エントリーDOI: 10.2210/pdb4zx2/pdb
• 関連するPDBエントリー: 1S95 4ZVZ
• 分子名称: Serine/threonine-protein phosphatase 5, MANGANESE (II) ION, (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ... (6 entities in total)
• 機能のキーワード: protein phosphatase 5, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38433.43

構造登録者

Chattopadhyay, D.,Swingle, M.R.,Salter, E.A.,Wierzbicki, A.,Honkanen, R.E. (登録日: 2015-05-19, 公開日: 2016-04-27, 最終更新日: 2023-09-27)

• 主引用文献: Chattopadhyay, D.,Swingle, M.R.,Salter, E.A.,Wood, E.,D'Arcy, B.,Zivanov, C.,Abney, K.,Musiyenko, A.,Rusin, S.F.,Kettenbach, A.,Yet, L.,Schroeder, C.E.,Golden, J.E.,Dunham, W.H.,Gingras, A.C.,Banerjee, S.,Forbes, D.,Wierzbicki, A.,Honkanen, R.E.; Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.; Biochem. Pharmacol., 109:14-26, 2016; PubMed: 27002182; DOI: 10.1016/j.bcp.2016.03.011

実験手法

X-RAY DIFFRACTION (1.23 Å)