4ZVR

Caspase-7 Variant 4 (V4) with reprogrammed substrate specificity due to Y230V/W232Y/S234V/Q276D substitutions bound to DEVD inhibitor.

4ZVR の概要

• エントリーDOI: 10.2210/pdb4zvr/pdb
• 関連するPDBエントリー: 1F1J 3EDR 4ZVO 4ZVP 4ZVQ 4ZVS 4ZVT 4ZVU
• 関連するBIRD辞書のPRD_ID: PRD_000422
• 分子名称: Caspase-7, Peptide ACE-ASP-GLU-VAL-ASJ, ... (4 entities in total)
• 機能のキーワード: directed evolution, protease, peptide inhibitor, designed active site specificity, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 71626.85

構造登録者

Hill, M.E.,MacPherson, D.J.,Hardy, J.A. (登録日: 2015-05-18, 公開日: 2016-04-20, 最終更新日: 2023-11-15)

• 主引用文献: Hill, M.E.,MacPherson, D.J.,Wu, P.,Julien, O.,Wells, J.A.,Hardy, J.A.; Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.; Acs Chem.Biol., 11:1603-1612, 2016; PubMed: 27032039; DOI: 10.1021/acschembio.5b00971

実験手法

X-RAY DIFFRACTION (2.3 Å)