4ZV8

Structure of CYP2B6 (Y226H/K262R) with additional mutation Y244W in complex with alpha-Pinene

Summary for 4ZV8

Entry DOI	10.2210/pdb4zv8/pdb
Related	3IBD 3QOA 3QU8 3UA5 4I91 4RQL 4RRT
Descriptor	Cytochrome P450 2B6, PROTOPORPHYRIN IX CONTAINING FE, (+)-alpha-Pinene, ... (5 entities in total)
Functional Keywords	cytochrome p450 2b6, monoxygenase, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	56410.91
Authors	Liu, J.,Shah, M.B.,Stout, C.D.,Halpert, J.R. (deposition date: 2015-05-18, release date: 2016-03-30, Last modification date: 2023-09-27)
Primary citation	Liu, J.,Shah, M.B.,Zhang, Q.,Stout, C.D.,Halpert, J.R.,Wilderman, P.R. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations. Biochemistry, 55:1997-2007, 2016 Cited by PubMed: 26982502 DOI: 10.1021/acs.biochem.5b01330 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.24 Å)

Structure validation