4ZN7

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Diethylstilbestrol

Summary for 4ZN7

• Entry DOI: 10.2210/pdb4zn7/pdb
• Related: 4PP6 4ZN9 4ZNH 4ZNS 4ZNT 4ZNU 4ZNV 4ZNW
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, DIETHYLSTILBESTROL, ... (4 entities in total)
• Functional Keywords: nuclear receptor transcription factor nucleus protein-ligand complex, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372; Nucleus: Q15596
• Total number of polymer chains: 4
• Total formula weight: 62355.35

Authors

Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Cavett, V.,Nowak, J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W. (deposition date: 2015-05-04, release date: 2016-05-04, Last modification date: 2023-09-27)

• Primary citation: Nwachukwu, J.C.,Srinivasan, S.,Zheng, Y.,Wang, S.,Min, J.,Dong, C.,Liao, Z.,Nowak, J.,Wright, N.J.,Houtman, R.,Carlson, K.E.,Josan, J.S.,Elemento, O.,Katzenellenbogen, J.A.,Zhou, H.B.,Nettles, K.W.; Predictive features of ligand-specific signaling through the estrogen receptor.; Mol.Syst.Biol., 12:864-864, 2016; PubMed: 27107013; DOI: 10.15252/msb.20156701

Experimental method

X-RAY DIFFRACTION (1.934 Å)