4ZL4

Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)

Summary for 4ZL4

• Entry DOI: 10.2210/pdb4zl4/pdb
• Related PRD ID: PRD_002168
• Descriptor: Aspartic protease PM5, N-[(benzyloxy)carbonyl]-O-carbamimidamido-L-homoseryl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl}-L-valinamide, SULFATE ION, ... (6 entities in total)
• Functional Keywords: malaria, inhibitor, aspartyl protease, pexel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Plasmodium vivax
• Total number of polymer chains: 2
• Total formula weight: 103740.46

Authors

Czabotar, P.E.,Hodder, A.N.,Smith, B.J.,Sleebs, B.E.,Gazdic, M.,Boddey, J.A.,Cowman, A.F. (deposition date: 2015-05-01, release date: 2015-07-15, Last modification date: 2023-09-27)

• Primary citation: Hodder, A.N.,Sleebs, B.E.,Czabotar, P.E.,Gazdik, M.,Xu, Y.,O'Neill, M.T.,Lopaticki, S.,Nebl, T.,Triglia, T.,Smith, B.J.,Lowes, K.,Boddey, J.A.,Cowman, A.F.; Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.; Nat.Struct.Mol.Biol., 22:590-596, 2015; PubMed: 26214367; DOI: 10.1038/nsmb.3061

Experimental method

X-RAY DIFFRACTION (2.37 Å)