4ZL4

Plasmepsin V from Plasmodium vivax bound to a transition state mimetic (WEHI-842)

4ZL4 の概要

• エントリーDOI: 10.2210/pdb4zl4/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002168
• 分子名称: Aspartic protease PM5, N-[(benzyloxy)carbonyl]-O-carbamimidamido-L-homoseryl-N-{(3S,4S)-3-hydroxy-6-methyl-1-oxo-1-[(2-phenylethyl)amino]heptan-4-yl}-L-valinamide, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: malaria, inhibitor, aspartyl protease, pexel, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Plasmodium vivax
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 103740.46

構造登録者

Czabotar, P.E.,Hodder, A.N.,Smith, B.J.,Sleebs, B.E.,Gazdic, M.,Boddey, J.A.,Cowman, A.F. (登録日: 2015-05-01, 公開日: 2015-07-15, 最終更新日: 2023-09-27)

• 主引用文献: Hodder, A.N.,Sleebs, B.E.,Czabotar, P.E.,Gazdik, M.,Xu, Y.,O'Neill, M.T.,Lopaticki, S.,Nebl, T.,Triglia, T.,Smith, B.J.,Lowes, K.,Boddey, J.A.,Cowman, A.F.; Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes.; Nat.Struct.Mol.Biol., 22:590-596, 2015; PubMed: 26214367; DOI: 10.1038/nsmb.3061

実験手法

X-RAY DIFFRACTION (2.37 Å)