4ZHZ

Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region with expelling one of the metal ions in the active site

Summary for 4ZHZ

• Entry DOI: 10.2210/pdb4zhz/pdb
• Related: 4YYL 4ZI0
• Descriptor: Polymerase acidic protein, 5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1); More
• Total number of polymer chains: 1
• Total formula weight: 23034.87

Authors

Fudo, S.,Yamamoto, N.,Nukaga, M.,Odagiri, T.,Tashiro, M.,Neya, S.,Hoshino, T. (deposition date: 2015-04-27, release date: 2015-05-13, Last modification date: 2023-11-08)

• Primary citation: Fudo, S.,Yamamoto, N.,Nukaga, M.,Odagiri, T.,Tashiro, M.,Hoshino, T.; Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit; Biochemistry, 55:2646-2660, 2016; PubMed: 27088785; DOI: 10.1021/acs.biochem.5b01087

Experimental method

X-RAY DIFFRACTION (2.5 Å)