4ZHZ

Endonuclease inhibitor bound to influenza strain H1N1 polymerase acidic subunit N-terminal region with expelling one of the metal ions in the active site

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 4P8 A 301

Chain	Residue
A	THR20
A	MN303
A	HOH408
A	HOH414
A	HOH440
A	TYR24
A	HIS41
A	GLU80
A	GLU119
A	ILE120
A	TYR130
A	LYS134
A	4P8302

---

site_id	AC2
Number of Residues	5
Details	binding site for residue 4P8 A 302

Chain	Residue
A	LYS34
A	TYR130
A	LYS137
A	4P8301
A	HOH412

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MN A 303

Chain	Residue
A	GLU80
A	LEU106
A	ASP108
A	GLU119
A	4P8301

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 304

Chain	Residue
A	ARG179
A	TRP188
A	ARG192

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Motif: {"description":"Nuclear localization signal 1 (NLS1)","evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8113737","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26252962","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27088785","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZI0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZQQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27088785","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4YYL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZI0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZQQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---