4ZHQ

Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex

Summary for 4ZHQ

• Entry DOI: 10.2210/pdb4zhq/pdb
• Related: 4ZI7 4ZOL 5BMV
• Related PRD ID: PRD_002173
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide, ... (13 entities in total)
• Functional Keywords: structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Rattus norvegicus (Rat); More
• Cellular location: Cytoplasm, cytoskeleton: Q2XVP4 P02554; Golgi apparatus : P63043
• Total number of polymer chains: 6
• Total formula weight: 265947.72

Authors

Wang, Y.,Zhang, R. (deposition date: 2015-04-26, release date: 2016-07-27, Last modification date: 2023-11-08)

• Primary citation: Wang, Y.,Benz, F.W.,Wu, Y.,Wang, Q.,Chen, Y.,Chen, X.,Li, H.,Zhang, Y.,Zhang, R.,Yang, J.; Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules; Mol.Pharmacol., 89:233-242, 2016; PubMed: 26660762; DOI: 10.1124/mol.115.100149

Experimental method

X-RAY DIFFRACTION (2.55 Å)