4ZFF
Dual-acting Fab 5A12 in complex with VEGF
Summary for 4ZFF
Entry DOI | 10.2210/pdb4zff/pdb |
Related | 4ZFG |
Descriptor | Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, Vascular endothelial growth factor A, ... (5 entities in total) |
Functional Keywords | fab, daf, angiogenesis, tie receptor, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted : P15692 |
Total number of polymer chains | 6 |
Total formula weight | 118451.12 |
Authors | Harris, S.F.,Wu, P. (deposition date: 2015-04-21, release date: 2015-07-01, Last modification date: 2015-09-16) |
Primary citation | Koenig, P.,Lee, C.V.,Sanowar, S.,Wu, P.,Stinson, J.,Harris, S.F.,Fuh, G. Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration. J.Biol.Chem., 290:21773-21786, 2015 Cited by PubMed: 26088137DOI: 10.1074/jbc.M115.662783 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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