4Z9A

Crystal structure of Low Molecular Weight Protein Tyrosine Phosphatase isoform A complexed with phenylmethanesulfonic acid

4Z9A の概要

• エントリーDOI: 10.2210/pdb4z9a/pdb
• 関連するPDBエントリー: 3N8I 4Z99 4Z9B 5PNT
• 分子名称: Low molecular weight phosphotyrosine protein phosphatase, GLYCEROL, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: protein tyrosine phosphatase, hydrolase, protein-ligand complex, phenylmethanesulfonic acid
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19211.69

構造登録者

Trivella, D.B.B.,Fonseca, E.M.B.,Scorsato, V.,Dias, M.P.,Aparicio, R. (登録日: 2015-04-10, 公開日: 2015-07-15, 最終更新日: 2023-09-27)

• 主引用文献: Fonseca, E.M.,Trivella, D.B.,Scorsato, V.,Dias, M.P.,Bazzo, N.L.,Mandapati, K.R.,de Oliveira, F.L.,Ferreira-Halder, C.V.,Pilli, R.A.,Miranda, P.C.,Aparicio, R.; Crystal structures of the apo form and a complex of human LMW-PTP with a phosphonic acid provide new evidence of a secondary site potentially related to the anchorage of natural substrates.; Bioorg.Med.Chem., 23:4462-4471, 2015; PubMed: 26117648; DOI: 10.1016/j.bmc.2015.06.017

実験手法

X-RAY DIFFRACTION (2.1 Å)