4Z8L

Crystal structure of DCAF1/SIV-MND VPX/MND SAMHD1 NTD ternary complex

Summary for 4Z8L

Entry DOI	10.2210/pdb4z8l/pdb
Descriptor	Protein VPRBP, Vpx protein, SAM domain and HD domain-containing protein, ... (5 entities in total)
Functional Keywords	hiv, antiviral defense, viral protein-vpx-binding protein complex, viral protein/vpx-binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	130491.18
Authors	Koharudin, L.M.,Wu, Y.,Calero, G.,Ahn, J.,Gronenborn, A.M. (deposition date: 2015-04-09, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	Wu, Y.,Koharudin, L.M.,Mehrens, J.,DeLucia, M.,Byeon, C.H.,Byeon, I.J.,Calero, G.,Ahn, J.,Gronenborn, A.M. Structural Basis of Clade-specific Engagement of SAMHD1 (Sterile alpha Motif and Histidine/Aspartate-containing Protein 1) Restriction Factors by Lentiviral Viral Protein X (Vpx) Virulence Factors. J.Biol.Chem., 290:17935-17945, 2015 Cited by PubMed: 26045556 DOI: 10.1074/jbc.M115.665513 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation