4Z8D

Antibacterial FabH Inhibitors with Validated Mode of Action in Haemophilus Influenzae by in vitro resistance mutation mapping

4Z8D の概要

• エントリーDOI: 10.2210/pdb4z8d/pdb
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 3, trans-4-[({[(2-chlorobenzyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: beta-ketoacyl-(acyl-carrier-protein) synthase iii, carbamate, structure based drug design, fatty acid biosynthesis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Escherichia coli O157:H7
• 細胞内の位置: Cytoplasm : P0A6R2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 67937.75

構造登録者

Lahiri, S.D. (登録日: 2015-04-08, 公開日: 2016-05-04, 最終更新日: 2024-03-06)

• 主引用文献: McKinney, D.C.,Eyermann, C.J.,Gu, R.F.,Hu, J.,Kazmirski, S.L.,Lahiri, S.D.,McKenzie, A.R.,Shapiro, A.B.,Breault, G.; Antibacterial FabH Inhibitors with Mode of Action Validated in Haemophilus influenzae by in Vitro Resistance Mutation Mapping.; Acs Infect Dis., 2:456-464, 2016; PubMed: 27626097; DOI: 10.1021/acsinfecdis.6b00053

実験手法

X-RAY DIFFRACTION (2 Å)