4Z7M

Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity

4Z7M の概要

• エントリーDOI: 10.2210/pdb4z7m/pdb
• 分子名称: Methionine aminopeptidase, MANGANESE (II) ION, N~2~-[(3,5-difluorophenyl)acetyl]-N-[(3S,7R)-1-methyl-2-oxo-7-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-yl]-L-alaninamide, ... (4 entities in total)
• 機能のキーワード: antibacterial, methionine aminopeptidase, azepinone, structure-based design, drug discovery, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58983.70

構造登録者

Rose, J.A.,Lahiri, S.D.,McKinney, D.C.,Albert, R.,Morningstar, M.,Shapiro, A.B.,Fisher, S.F.,Fleming, P.R. (登録日: 2015-04-07, 公開日: 2016-04-13, 最終更新日: 2024-03-06)

• 主引用文献: Rose, J.A.,Lahiri, S.D.,McKinney, D.C.,Albert, R.,Morningstar, M.,Shapiro, A.B.,Fisher, S.F.,Fleming, P.R.; Novel Inhibitors of Bacterial Methionine Aminopeptidase with Broad-Spectrum Biochemical Activity; To be Published,

実験手法

X-RAY DIFFRACTION (1.43 Å)