4Z6A
Crystal Structure of a FVIIa-Trypsin Chimera (YT) in Complex with Soluble Tissue Factor
Summary for 4Z6A
Entry DOI | 10.2210/pdb4z6a/pdb |
Related | 4YLQ |
Related PRD ID | PRD_000369 |
Descriptor | Coagulation factor VII, Tissue factor, beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | trypsin-fold, protein-protein complex, hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P08709 P08709 Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726 |
Total number of polymer chains | 3 |
Total formula weight | 62624.06 |
Authors | Sorensen, A.B.,Svensson, L.A.,Gandhi, P.S. (deposition date: 2015-04-04, release date: 2015-12-30, Last modification date: 2024-01-10) |
Primary citation | Sorensen, A.B.,Madsen, J.J.,Svensson, L.A.,Pedersen, A.A.,stergaard, H.,Overgaard, M.T.,Olsen, O.H.,Gandhi, P.S. Molecular Basis of Enhanced Activity in Factor VIIa-Trypsin Variants Conveys Insights into Tissue Factor-mediated Allosteric Regulation of Factor VIIa Activity. J.Biol.Chem., 291:4671-4683, 2016 Cited by PubMed: 26694616DOI: 10.1074/jbc.M115.698613 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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