4Z53

Quinolone(Trovafloxacin)-DNA cleavage complex of topoisomerase IV from S. pneumoniae

Summary for 4Z53

• Entry DOI: 10.2210/pdb4z53/pdb
• Related: 3KSA 3KSB 3RAD 3RAE 3RAF 4I3H 4KOE 4PXP
• Descriptor: DNA topoisomerase 4 subunit B,DNA topoisomerase 4 subunit A, E-site DNA, MAGNESIUM ION, ... (8 entities in total)
• Functional Keywords: topo iv, cleavage complex, dna, quinolone, isomerase
• Biological source: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4); More
• Cellular location: Cell membrane ; Peripheral membrane protein : P72525
• Total number of polymer chains: 6
• Total formula weight: 180294.04

Authors

Laponogov, I.,Veselkov, D.A.,Pan, X.-S.,Selvarajah, J.,Crevel, I.M.-T.,Fisher, L.M.,Sanderson, M.R. (deposition date: 2015-04-02, release date: 2016-09-14, Last modification date: 2024-01-10)

• Primary citation: Laponogov, I.,Veselkov, D.A.,Pan, X.-S.,Selvarajah, J.,Crevel, I.M.-T.,Fisher, L.M.,Sanderson, M.R.; Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.26 Å)