Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005694 | cellular_component | chromosome |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006265 | biological_process | DNA topological change |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003918 | molecular_function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005694 | cellular_component | chromosome |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue MG A 1501 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 1502 |
| Chain | Residue |
| A | GLU433 |
| A | ASP506 |
| A | ASP508 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue MG B 1501 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 1502 |
| Chain | Residue |
| B | GLU433 |
| B | ASP506 |
| B | ASP508 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue TR6 F 101 |
| Chain | Residue |
| A | SER1079 |
| A | MG1501 |
| B | ARG1117 |
| E | DT15 |
| F | DC4 |
| F | DA5 |
| H | DG1 |
| A | ARG456 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue TR6 H 101 |
| Chain | Residue |
| A | ARG1117 |
| B | GLY434 |
| B | ARG456 |
| B | GLY457 |
| B | GLU475 |
| B | SER1079 |
| B | MG1501 |
| F | DA1 |
| G | DT15 |
| H | DT4 |
| H | DA5 |
Functional Information from PROSITE/UniProt
| site_id | PS00177 |
| Number of Residues | 9 |
| Details | TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG |
| Chain | Residue | Details |
| A | LEU431-GLY439 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU433 | |
| A | ASP506 | |
| A | ASP508 | |
| B | GLU433 | |
| B | ASP506 | |
| B | ASP508 | |
| Chain | Residue | Details |
| A | LYS458 | |
| A | ASN461 | |
| A | HIS513 | |
| A | ARG629 | |
| B | LYS458 | |
| B | ASN461 | |
| B | HIS513 | |
| B | ARG629 | |
| Chain | Residue | Details |
| A | TYR1118 | |
| B | TYR1118 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | SITE: Interaction with DNA |
| Chain | Residue | Details |
| A | LYS1038 | |
| B | LYS1093 | |
| A | HIS1074 | |
| A | HIS1076 | |
| A | ARG1087 | |
| A | LYS1093 | |
| B | LYS1038 | |
| B | HIS1074 | |
| B | HIS1076 | |
| B | ARG1087 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Transition state stabilizer |
| Chain | Residue | Details |
| A | ARG1117 | |
| B | ARG1117 | |
