4Z1H
Crystal structure of human Trap1 with SMTIN-P01
Summary for 4Z1H
Entry DOI | 10.2210/pdb4z1h/pdb |
Related | 4z1f 4z1g 4z1i |
Descriptor | Heat shock protein 75 kDa, mitochondrial, 8-[(6-iodo-1,3-benzodioxol-5-yl)sulfanyl]-9-[6-(triphenyl-lambda~5~-phosphanyl)hexyl]-9H-purin-6-amine (3 entities in total) |
Functional Keywords | mitochondrial hsp90, chaperone |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion : Q12931 |
Total number of polymer chains | 1 |
Total formula weight | 58181.73 |
Authors | |
Primary citation | Lee, C.,Park, H.K.,Jeong, H.,Lim, J.,Lee, A.J.,Cheon, K.Y.,Kim, C.S.,Thomas, A.P.,Bae, B.,Kim, N.D.,Kim, S.H.,Suh, P.G.,Ryu, J.H.,Kang, B.H. Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 J.Am.Chem.Soc., 137:4358-4367, 2015 Cited by PubMed: 25785725DOI: 10.1021/ja511893n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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