4YZS

Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling

Summary for 4YZS

Entry DOI	10.2210/pdb4yzs/pdb
Descriptor	Eukaryotic translation initiation factor 2-alpha kinase 3, TUNGSTEN ION (2 entities in total)
Functional Keywords	perk, upr, er stress, tetramer, upr activation, upr sensor, unfolded protein, proteostasis, signaling protein
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Single-pass type I membrane protein: Q9NZJ5
Total number of polymer chains	2
Total formula weight	68600.11
Authors	Carrara, M.,Prischi, F.,Ali, M.M.U. (deposition date: 2015-03-25, release date: 2015-05-13, Last modification date: 2017-09-13)
Primary citation	Carrara, M.,Prischi, F.,Nowak, P.R.,Ali, M.M. Crystal structures reveal transient PERK luminal domain tetramerization in endoplasmic reticulum stress signaling. Embo J., 34:1589-1600, 2015 Cited by PubMed: 25925385 DOI: 10.15252/embj.201489183 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.14 Å)

Structure validation