4YZS

Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Eukaryotic translation initiation factor 2-alpha kinase 3	polymer	305	34116.2	2	UniProt (Q9NZJ5)	Homo sapiens (Human)	PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,HsPEK
2	C, D (A, B)	TUNGSTEN ION	non-polymer		183.8	2	Chemie (W)

Sequence modifications

A, B: 104 - 403 (UniProt: Q9NZJ5)

PDB	External Database	Details
Gly 99	-	expression tag
Pro 100	-	expression tag
His 101	-	expression tag
Met 102	-	expression tag
Ala 103	-	expression tag
Arg 167	Gln 166	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68232.4
Non-Polymers*	Number of molecules	2
	Total formula weight	367.7
All*	Total formula weight	68600.1

*Water molecules are not included.