4YZS
Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Eukaryotic translation initiation factor 2-alpha kinase 3 | polymer | 305 | 34116.2 | 2 | UniProt (Q9NZJ5) In PDB | Homo sapiens (Human) | PRKR-like endoplasmic reticulum kinase,Pancreatic eIF2-alpha kinase,HsPEK |
2 | A, B | TUNGSTEN ION | non-polymer | 183.8 | 2 | Chemie (W) |
Sequence modifications
A, B: 104 - 403 (UniProt: Q9NZJ5)
PDB | External Database | Details |
---|---|---|
Gly 99 | - | expression tag |
Pro 100 | - | expression tag |
His 101 | - | expression tag |
Met 102 | - | expression tag |
Ala 103 | - | expression tag |
Arg 167 | Gln 166 | variant |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 68232.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 367.7 | |
All* | Total formula weight | 68600.1 |