4YYL

Phenolic acid derivative bound to influenza strain H1N1 polymerase subunit PA endonuclease

Summary for 4YYL

• Entry DOI: 10.2210/pdb4yyl/pdb
• Descriptor: Polymerase acidic protein, 2-(4-fluorophenoxy)-1-(2,3,4-trihydroxyphenyl)ethanone, MANGANESE (II) ION, ... (5 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1); More
• Total number of polymer chains: 1
• Total formula weight: 23341.13

Authors

Fudo, S.,Yamamoto, N.,Nukaga, M.,Odagiri, T.,Tashiro, M.,Neya, S.,Hoshino, T. (deposition date: 2015-03-24, release date: 2015-04-29, Last modification date: 2023-11-08)

• Primary citation: Fudo, S.,Yamamoto, N.,Nukaga, M.,Odagiri, T.,Tashiro, M.,Neya, S.,Hoshino, T.; Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase; Bioorg.Med.Chem., 23:5466-5475, 2015; PubMed: 26252962; DOI: 10.1016/j.bmc.2015.07.046

Experimental method

X-RAY DIFFRACTION (1.905 Å)