4YYL

Phenolic acid derivative bound to influenza strain H1N1 polymerase subunit PA endonuclease

4YYL の概要

• エントリーDOI: 10.2210/pdb4yyl/pdb
• 分子名称: Polymerase acidic protein, 2-(4-fluorophenoxy)-1-(2,3,4-trihydroxyphenyl)ethanone, MANGANESE (II) ION, ... (5 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Influenza A virus (strain A/Puerto Rico/8/1934 H1N1); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23341.13

構造登録者

Fudo, S.,Yamamoto, N.,Nukaga, M.,Odagiri, T.,Tashiro, M.,Neya, S.,Hoshino, T. (登録日: 2015-03-24, 公開日: 2015-04-29, 最終更新日: 2023-11-08)

• 主引用文献: Fudo, S.,Yamamoto, N.,Nukaga, M.,Odagiri, T.,Tashiro, M.,Neya, S.,Hoshino, T.; Structural and computational study on inhibitory compounds for endonuclease activity of influenza virus polymerase; Bioorg.Med.Chem., 23:5466-5475, 2015; PubMed: 26252962; DOI: 10.1016/j.bmc.2015.07.046

実験手法

X-RAY DIFFRACTION (1.905 Å)