4YX4
Human Carbonic Anhydrase II complexed with an inhibitor with a benzenesulfonamide group (1).
Summary for 4YX4
Entry DOI | 10.2210/pdb4yx4/pdb |
Related | 3KS3 |
Descriptor | Carbonic anhydrase 2, ZINC ION, MERCURIBENZOIC ACID, ... (6 entities in total) |
Functional Keywords | protein-ligand-complex, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29925.46 |
Authors | Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2015-03-22, release date: 2016-02-03, Last modification date: 2024-01-10) |
Primary citation | Gaspari, R.,Rechlin, C.,Heine, A.,Bottegoni, G.,Rocchia, W.,Schwarz, D.,Bomke, J.,Gerber, H.D.,Klebe, G.,Cavalli, A. Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies. J.Med.Chem., 59:4245-4256, 2016 Cited by PubMed: 26700575DOI: 10.1021/acs.jmedchem.5b01643 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.01 Å) |
Structure validation
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