4YW5
Crystal Structure of Streptococcus pneumoniae NanC, complex with oseltamivir carboxylate
Summary for 4YW5
| Entry DOI | 10.2210/pdb4yw5/pdb |
| Descriptor | Neuraminidase C, (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, GLYCEROL, ... (5 entities in total) |
| Functional Keywords | sialidase, neuraminidase, oseltamivir, cbm40, hydrolase |
| Biological source | Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) |
| Total number of polymer chains | 2 |
| Total formula weight | 149416.83 |
| Authors | Owen, C.D.,Lukacik, P.,Potter, J.A.,Walsh, M.,Taylor, G.L. (deposition date: 2015-03-20, release date: 2015-09-23, Last modification date: 2024-01-10) |
| Primary citation | Owen, C.D.,Lukacik, P.,Potter, J.A.,Sleator, O.,Taylor, G.L.,Walsh, M.A. Streptococcus pneumoniae NanC: STRUCTURAL INSIGHTS INTO THE SPECIFICITY AND MECHANISM OF A SIALIDASE THAT PRODUCES A SIALIDASE INHIBITOR. J.Biol.Chem., 290:27736-27748, 2015 Cited by PubMed: 26370075DOI: 10.1074/jbc.M115.673632 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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