4YW5
Crystal Structure of Streptococcus pneumoniae NanC, complex with oseltamivir carboxylate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0009313 | biological_process | oligosaccharide catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue G39 A 801 |
| Chain | Residue |
| A | ARG290 |
| A | ARG662 |
| A | TYR695 |
| A | TRP716 |
| A | GOL802 |
| A | HOH911 |
| A | HOH917 |
| A | ARG309 |
| A | ASP315 |
| A | ASP372 |
| A | PHE396 |
| A | TYR533 |
| A | TYR553 |
| A | SER582 |
| A | ARG600 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 802 |
| Chain | Residue |
| A | ASP315 |
| A | SER715 |
| A | G39801 |
| A | HOH903 |
| A | HOH917 |
| A | HOH1003 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 803 |
| Chain | Residue |
| A | ASP449 |
| A | ASN451 |
| A | GLY453 |
| A | HIS485 |
| A | ASN487 |
| A | HOH1025 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 804 |
| Chain | Residue |
| A | ARG173 |
| A | SER176 |
| A | ALA205 |
| A | ASN206 |
| A | THR208 |
| A | LEU276 |
| A | LYS724 |
| A | ASN725 |
| A | VAL726 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 805 |
| Chain | Residue |
| A | ASP315 |
| A | PHE316 |
| A | LEU317 |
| A | ASN318 |
| A | GLY366 |
| A | GLY367 |
| A | THR369 |
| A | MET390 |
| A | PRO391 |
| A | GLY393 |
| A | VAL394 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 806 |
| Chain | Residue |
| A | LYS209 |
| A | GLU212 |
| A | GLU352 |
| A | LYS724 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 807 |
| Chain | Residue |
| A | PRO348 |
| A | GLN465 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue G39 B 801 |
| Chain | Residue |
| B | ARG290 |
| B | ASP315 |
| B | ASP372 |
| B | TYR533 |
| B | TYR553 |
| B | SER582 |
| B | ARG600 |
| B | ARG662 |
| B | TYR695 |
| B | TRP716 |
| B | HOH921 |
| B | HOH1015 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 802 |
| Chain | Residue |
| B | ARG173 |
| B | SER176 |
| B | ALA205 |
| B | ASN206 |
| B | THR208 |
| B | LYS724 |
| B | ASN725 |
| B | VAL726 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 803 |
| Chain | Residue |
| B | LYS209 |
| B | VAL211 |
| B | GLU212 |
| B | GLU352 |
| B | LYS724 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 804 |
| Chain | Residue |
| B | ARG290 |
| B | ASP315 |
| B | PHE316 |
| B | SER715 |
| B | HOH921 |
| B | HOH942 |
| B | HOH997 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 805 |
| Chain | Residue |
| B | ASP315 |
| B | PHE316 |
| B | LEU317 |
| B | ASN318 |
| B | GLY366 |
| B | GLY367 |
| B | PRO391 |
| B | GLY393 |
| B | VAL394 |
