4YU1
Human Aldose Reductase complexed with Schl12134 (3-[5-(3-nitrophenyl)-2-thienyl]propanoic acid) at 1.02 A
Summary for 4YU1
Entry DOI | 10.2210/pdb4yu1/pdb |
Related | 2IKG 2IKH 3DN5 4NKC 4PR4 4PRR 4PRT |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid, ... (4 entities in total) |
Functional Keywords | tim-barrel, oxidoreductase, protein-ligand-complex |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36919.04 |
Authors | Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2015-03-18, release date: 2016-03-23, Last modification date: 2024-01-10) |
Primary citation | Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G. Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.02 Å) |
Structure validation
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