4YU1

Human Aldose Reductase complexed with Schl12134 (3-[5-(3-nitrophenyl)-2-thienyl]propanoic acid) at 1.02 A

Summary for 4YU1

• Entry DOI: 10.2210/pdb4yu1/pdb
• Related: 2IKG 2IKH 3DN5 4NKC 4PR4 4PRR 4PRT
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid, ... (4 entities in total)
• Functional Keywords: tim-barrel, oxidoreductase, protein-ligand-complex
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 36919.04

Authors

Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2015-03-18, release date: 2016-03-23, Last modification date: 2024-01-10)

• Primary citation: Rechlin, C.,Heine, A.,Ortmann, R.,Schlitzer, M.,Klebe, G.; Keys to open the specificity pocket: Biphenylic Inhibitors of the human aldose reductase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.02 Å)