4YRG
Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (6-bromopyridin-2-yl)methanol (Chem 149)
Summary for 4YRG
| Entry DOI | 10.2210/pdb4yrg/pdb |
| Related | 4YP0 4YPF 4YRC 4YRE 4YRF 4YRI 4YRJ 4YRK 4YRL 4YRM 4YRN 4YRO 4YRP 4YRQ 4YRR 4YRS 4YRT |
| Descriptor | Histidyl-tRNA synthetase, HISTIDINE, (6-bromopyridin-2-yl)methanol, ... (7 entities in total) |
| Functional Keywords | ligase, aminoacyl-trna synthetase, aars, hisrs, trypanosoma cruzi, protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
| Biological source | Trypanosoma cruzi (strain CL Brener) |
| Total number of polymer chains | 1 |
| Total formula weight | 52036.30 |
| Authors | Koh, C.-Y.,Hol, W.G.J. (deposition date: 2015-03-15, release date: 2015-08-12, Last modification date: 2023-09-27) |
| Primary citation | Koh, C.Y.,Siddaramaiah, L.K.,Ranade, R.M.,Nguyen, J.,Jian, T.,Zhang, Z.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G. A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallogr. D Biol. Crystallogr., 71:1684-1698, 2015 Cited by PubMed: 26249349DOI: 10.1107/S1399004715007683 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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