4YRG

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with (6-bromopyridin-2-yl)methanol (Chem 149)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004821	molecular_function	histidine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006412	biological_process	translation
A	0006427	biological_process	histidyl-tRNA aminoacylation
A	0016874	molecular_function	ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue HIS A 501

Chain	Residue
A	GLU126
A	GLY359
A	PHE360
A	GLY361
A	HOH606
A	HOH613
A	HOH617
A	HOH622
A	THR128
A	GLN170
A	ASN172
A	ASP174
A	LEU316
A	TYR318
A	TYR319
A	TYR342

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site_id	AC2
Number of Residues	10
Details	binding site for residue 4HU A 502

Chain	Residue
A	PRO125
A	CYS154
A	TRP155
A	ARG156
A	ARG165
A	ARG166
A	GLU167
A	HIS168
A	SO4505
A	HOH606

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site_id	AC3
Number of Residues	4
Details	binding site for residue EDO A 503

Chain	Residue
A	THR115
A	GLY117
A	TYR157
A	ARG166

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site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 504

Chain	Residue
A	ARG69
A	ARG69
A	HIS76
A	HOH602
A	HOH602

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site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 A 505

Chain	Residue
A	HIS168
A	ARG334
A	GLY363
A	ASP364
A	CYS365
A	VAL366
A	4HU502

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site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 A 506

Chain	Residue
A	ARG196
A	SER201
A	SER202
A	TRP305

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site_id	AC7
Number of Residues	4
Details	binding site for residue DMS A 507

Chain	Residue
A	GLU96
A	LEU97
A	ILE99
A	ARG100

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site_id	AC8
Number of Residues	3
Details	binding site for residue DMS A 508

Chain	Residue
A	TRP193
A	ARG196
A	SER197

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