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4YRF

Crystal structure of T. cruzi Histidyl-tRNA synthetase in complex with 5-bromopyridin-2(1H)-one (Chem 148)

Summary for 4YRF
Entry DOI10.2210/pdb4yrf/pdb
Related4YP0 4YPF 4YRC 4YRE 4YRG 4YRI 4YRJ 4YRK 4YRL 4YRM 4YRN 4YRO 4YRP 4YRQ 4YRR 4YRS 4YRT
DescriptorHistidyl-tRNA synthetase, putative, HISTIDINE, 5-bromopyridin-2(1H)-one, ... (7 entities in total)
Functional Keywordsligase, aminoacyl-trna synthetase, aars, hisrs, trypanosoma cruzi, protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceTrypanosoma cruzi (strain CL Brener)
Total number of polymer chains1
Total formula weight52022.27
Authors
Koh, C.-Y.,Hol, W.G.J. (deposition date: 2015-03-15, release date: 2015-08-19, Last modification date: 2023-09-27)
Primary citationKoh, C.Y.,Kallur Siddaramaiah, L.,Ranade, R.M.,Nguyen, J.,Jian, T.,Zhang, Z.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr.,Sect.D, 71:1684-1698, 2015
Cited by
PubMed: 26249349
DOI: 10.1107/S1399004715007683
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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