4YPG
Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody
Summary for 4YPG
| Entry DOI | 10.2210/pdb4ypg/pdb |
| Descriptor | Sifalimumab light chain, Sifalimumab heavy chain, Interferon alpha-2, ... (5 entities in total) |
| Functional Keywords | therapeutic mab, ifn-alpha2a, immune system |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 131149.01 |
| Authors | Oganesyan, V.,Dall'Acqua, W.F. (deposition date: 2015-03-12, release date: 2015-05-06, Last modification date: 2023-09-27) |
| Primary citation | Oganesyan, V.,Peng, L.,Woods, R.M.,Wu, H.,Dall'Acqua, W.F. Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab. J.Biol.Chem., 290:14979-14985, 2015 Cited by PubMed: 25925951DOI: 10.1074/jbc.M115.652156 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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