4YPG

Structural Insights Into the Neutralization Properties of a Human Anti-Interferon Monoclonal Antibody

4YPG の概要

• エントリーDOI: 10.2210/pdb4ypg/pdb
• 分子名称: Sifalimumab light chain, Sifalimumab heavy chain, Interferon alpha-2, ... (5 entities in total)
• 機能のキーワード: therapeutic mab, ifn-alpha2a, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 131149.01

構造登録者

Oganesyan, V.,Dall'Acqua, W.F. (登録日: 2015-03-12, 公開日: 2015-05-06, 最終更新日: 2023-09-27)

• 主引用文献: Oganesyan, V.,Peng, L.,Woods, R.M.,Wu, H.,Dall'Acqua, W.F.; Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab.; J.Biol.Chem., 290:14979-14985, 2015; PubMed: 25925951; DOI: 10.1074/jbc.M115.652156

実験手法

X-RAY DIFFRACTION (3 Å)