4YNQ

TREX1-dsDNA complex

Summary for 4YNQ

• Entry DOI: 10.2210/pdb4ynq/pdb
• Descriptor: Three-prime repair exonuclease 1, DNA (24-MER), DNA (5'-D(P*GP*TP*GP*CP*TP*GP*AP*CP*GP*TP*CP*AP*GP*CP*AP*CP*GP*AP*CP*G)-3'), ... (6 entities in total)
• Functional Keywords: protein-dna complex, exonuclease, trex1, hydrolase-dna complex, hydrolase/dna
• Biological source: Mus musculus (Mouse); More
• Cellular location: Nucleus: Q91XB0
• Total number of polymer chains: 8
• Total formula weight: 128410.97

Authors

Fye, J.M.,Harvey, S.,Perrino, F.W.,Hollis, T. (deposition date: 2015-03-10, release date: 2015-05-27, Last modification date: 2023-09-27)

• Primary citation: Grieves, J.L.,Fye, J.M.,Harvey, S.,Grayson, J.M.,Hollis, T.,Perrino, F.W.; Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.; Proc.Natl.Acad.Sci.USA, 112:5117-5122, 2015; PubMed: 25848017; DOI: 10.1073/pnas.1423804112

Experimental method

X-RAY DIFFRACTION (2.8 Å)