4YN0

Crystal structure of APP E2 domain in complex with DR6 CRD domain

4YN0 の概要

• エントリーDOI: 10.2210/pdb4yn0/pdb
• 分子名称: Tumor necrosis factor receptor superfamily member 21, Amyloid beta A4 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: alzheimer, neuron pruning, amyloid precursor protein, apoptosis-cell adhesion complex, apoptosis/cell adhesion
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 48427.18

構造登録者

Xu, K.,Nikolov, D. (登録日: 2015-03-08, 公開日: 2015-04-15, 最終更新日: 2024-10-30)

主引用文献

Xu, K.,Olsen, O.,Tzvetkova-Robev, D.,Tessier-Lavigne, M.,Nikolov, D.B.
The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation.
Genes Dev., 29:785-790, 2015

PubMed Abstract: The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer's disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibit synapse formation. Here, we report the crystal structure of the DR6 ectodomain in complex with the E2 domain of APP and show that it supports a model for APP-induced dimerization and activation of cell surface DR6.

PubMed: 25838500
DOI: 10.1101/gad.257675.114

実験手法

X-RAY DIFFRACTION (2.2 Å)