4YMB
Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111
Summary for 4YMB
Entry DOI | 10.2210/pdb4ymb/pdb |
Related | 4E0X |
Descriptor | Glutamate receptor ionotropic, kainate 1,Glutamate receptor ionotropic, kainate 1, (3R,4S)-3-(3-carboxyphenyl)-4-propyl-L-proline, ACETATE ION, ... (7 entities in total) |
Functional Keywords | ionotropic glutamate receptor, kainate receptor gluk1, ligand-binding domain, antagonist, signaling protein, fusion protein |
Biological source | Rattus norvegicus (Rat) More |
Cellular location | Cell membrane; Multi-pass membrane protein: P22756 |
Total number of polymer chains | 2 |
Total formula weight | 59317.71 |
Authors | Moller, C.,Tapken, D.,Kastrup, J.S.,Frydenvang, K. (deposition date: 2015-03-06, release date: 2015-08-05, Last modification date: 2024-01-10) |
Primary citation | Krogsgaard-Larsen, N.,Storgaard, M.,Moller, C.,Demmer, C.S.,Hansen, J.,Han, L.,Monrad, R.N.,Nielsen, B.,Tapken, D.,Pickering, D.S.,Kastrup, J.S.,Frydenvang, K.,Bunch, L. Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid. J.Med.Chem., 58:6131-6150, 2015 Cited by PubMed: 26200741DOI: 10.1021/acs.jmedchem.5b00750 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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