4YM9

Crystal structure of Porcine Pancreatic Elastase (PPE) in complex with the novel inhibitor JM102

Summary for 4YM9

Entry DOI	10.2210/pdb4ym9/pdb
Descriptor	Chymotrypsin-like elastase family member 1, 2-ethyl-2-(hydroxymethyl)-N-(6-methylpyridin-3-yl)butanamide, SULFATE ION, ... (7 entities in total)
Functional Keywords	porcine pancreatic elastase, inhibitor, hydrolase
Biological source	Sus scrofa (Pig)
Total number of polymer chains	1
Total formula weight	27055.95
Authors	Hofbauer, S.,Brito, J.A.,Mulchande, J.,Nogly, P.,Pessanha, M.,Moreira, R.,Archer, M. (deposition date: 2015-03-06, release date: 2016-06-29, Last modification date: 2024-01-10)
Primary citation	Ruivo, E.F.,Goncalves, L.M.,Carvalho, L.A.,Guedes, R.C.,Hofbauer, S.,Brito, J.A.,Archer, M.,Moreira, R.,Lucas, S.D. Clickable 4-Oxo-beta-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes. ChemMedChem, 11:2037-2042, 2016 Cited by PubMed: 27465595 DOI: 10.1002/cmdc.201600258 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation