4YLL

Crystal structure of DYRK1AA in complex with 10-Bromo-substituted 11H-indolo[3,2-c]quinolone-6-carboxylic acid inhibitor 5t

Summary for 4YLL

Entry DOI	10.2210/pdb4yll/pdb
Related	4YLJ 4YLK
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	halogen, inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q13627
Total number of polymer chains	1
Total formula weight	43587.52
Authors	Chaikuad, A.,Falke, H.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-03-05, release date: 2015-03-25, Last modification date: 2023-11-15)
Primary citation	Falke, H.,Chaikuad, A.,Becker, A.,Loaec, N.,Lozach, O.,Abu Jhaisha, S.,Becker, W.,Jones, P.G.,Preu, L.,Baumann, K.,Knapp, S.,Meijer, L.,Kunick, C. 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A. J.Med.Chem., 58:3131-3143, 2015 Cited by PubMed: 25730262 DOI: 10.1021/jm501994d PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation