4YLL
Crystal structure of DYRK1AA in complex with 10-Bromo-substituted 11H-indolo[3,2-c]quinolone-6-carboxylic acid inhibitor 5t
Summary for 4YLL
Entry DOI | 10.2210/pdb4yll/pdb |
Related | 4YLJ 4YLK |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, SULFATE ION, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | halogen, inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q13627 |
Total number of polymer chains | 1 |
Total formula weight | 43587.52 |
Authors | Chaikuad, A.,Falke, H.,Krojer, T.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Kunick, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2015-03-05, release date: 2015-03-25, Last modification date: 2023-11-15) |
Primary citation | Falke, H.,Chaikuad, A.,Becker, A.,Loaec, N.,Lozach, O.,Abu Jhaisha, S.,Becker, W.,Jones, P.G.,Preu, L.,Baumann, K.,Knapp, S.,Meijer, L.,Kunick, C. 10-Iodo-11H-indolo[3,2-c]quinoline-6-carboxylic Acids Are Selective Inhibitors of DYRK1A. J.Med.Chem., 58:3131-3143, 2015 Cited by PubMed: 25730262DOI: 10.1021/jm501994d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
Download full validation report