4YLL
Crystal structure of DYRK1AA in complex with 10-Bromo-substituted 11H-indolo[3,2-c]quinolone-6-carboxylic acid inhibitor 5t
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 361 | 42081.5 | 1 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (Human) | Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, hMNB |
| 2 | B, C, D, E, F (A) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | G, H, I, J, K... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 4 | P (A) | 10-bromo-2-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acid | non-polymer | 467.1 | 1 | Chemie (4E3) | |||
| 5 | Q (A) | water | water | 18.0 | 577 | Chemie (HOH) |
Sequence modifications
A: 127 - 485 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Ser 125 | - | expression tag |
| Met 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42081.5 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1506.0 | |
| All* | Total formula weight | 43587.5 |
