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4YJT

THE KINASE DOMAIN OF HUMAN SPLEEN TYROSINE (SYK) IN COMPLEX WITH GTC000233

Summary for 4YJT
Entry DOI10.2210/pdb4yjt/pdb
DescriptorTyrosine-protein kinase SYK, GLYCEROL, N~2~-(1,1-dioxido-2,3-dihydro-1,2-benzothiazol-6-yl)-N~4~-ethyl-5-fluoro-N~4~-(1H-indazol-4-yl)pyrimidine-2,4-diamine, ... (4 entities in total)
Functional Keywordssyk, non-receptor tyrosine kinase, spleen tyrosine kinase, transferase, phosphorylation, transferase-transferase inhibitor complex
Biological sourceHomo sapiens (Human)
Cellular locationCell membrane : P43405
Total number of polymer chains1
Total formula weight33342.17
Authors
Somers, D.O.,Neu, M.,Stuckey, J. (deposition date: 2015-03-03, release date: 2015-09-30)
Primary citationLiddle, J.,Atkinson, F.L.,Barker, M.D.,Carter, P.S.,Curtis, N.R.,Davis, R.P.,Douault, C.,Dickson, M.C.,Elwes, D.,Garton, N.S.,Gray, M.,Hayhow, T.G.,Hobbs, C.I.,Jones, E.,Leach, S.,Leavens, K.,Lewis, H.D.,McCleary, S.,Neu, M.,Patel, V.K.,Preston, A.G.,Ramirez-Molina, C.,Shipley, T.J.,Skone, P.A.,Smithers, N.,Somers, D.O.,Walker, A.L.,Watson, R.J.,Weingarten, G.G.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg. Med. Chem. Lett., 21:6188-6194, 2011
Cited by
PubMed: 21903390
DOI: 10.1016/j.bmcl.2011.07.082
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.52 Å)
Structure validation

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